Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[ALS and excitatory amino acid].

Brain and nerve = Shinkei kenkyu no shinpo - 1 Oct 2007

Aizawa Hitoshi, Kwak Shin

Abstract excerpt

AMPA receptor, one of ionotropic glutamate receptors, has been proposed to play a critical role to initiate the neuronal death cascade in motor neuron disease by an increase of Ca2+ influx. There are at least two mechanisms to increase Ca2+ influx through Ca2+-permiable AMPA receptor: a decrease of RNA editing efficacy at the GluR2 Q/R site and a decrease of GluR2 level relative to AMPA receptor subunits....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Superoxide Dismutase-1
Share to Adenosine Deaminase
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Death

Share to Motor Neurons

Share to Receptors, AMPA

Share to RNA Editing

Share to Superoxide Dismutase

Source

Identifiers

PMID: 17969352

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[ALS and excitatory amino acid].PMID 17969352Read ↗

[AMPA receptor-mediated neuronal death and amyotrophic lateral sclerosis].Semantic proximity Read ↗

GluR2 Deficiency Accelerates Motor Neuron Degeneration in a Mouse Model of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunitSemantic proximity Read ↗

Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2Semantic proximity Read ↗

The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice.Semantic proximity Read ↗

Role of excitotoxicity in the degeneration of motor neurones in ALSSemantic proximity Read ↗

Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA.Semantic proximity Read ↗

Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model.Semantic proximity Read ↗

Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related NeurodegenerationSemantic proximity Read ↗

Cu/Zn-superoxide dismutase (GLY93-->ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture.Semantic proximity Read ↗

Mechanisms of disease: motoneuron disease aggravated by transgenic expression of a functionally modified AMPA receptor subunit.Semantic proximity Read ↗

When Does ALS Start? ADAR2?GluA2 Hypothesis for the Etiology of Sporadic ALSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.