Article

Multi-omics analyses of early-onset familial Alzheimer’s disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms

2023-11-02

Abstract excerpt

Sanfilippo syndrome (mucopolysaccharidosis type III, MPSIII) causes childhood dementia, while Alzheimer’s disease is the most common type of adult-onset dementia. There is no cure for either of these diseases, and therapeutic options are extremely limited. Increasing evidence suggests commonalities in the pathogenesis of these diseases. However, a direct molecular-level comparison of these diseases has never been...

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Literature Corpus work: d8cf98f5-cfd6-5698-91e2-665511de4ecd
DOI: 10.1101/2023.10.31.564867

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