Article

Secretome proteomics-based targeting of inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) and clusterin (Clu) mitigates p53 amyloid–mediated tumorigenesis in oral carcinoma

2026-02-19

Abstract excerpt

<title>Abstract</title> <p>Oral cancer, a major form of head and neck cancer (HNC), remains clinically challenging due to its aggressiveness, and therapeutic resistance. Tumor microenvironment (TME) is one of the key factors of cancer progression which strongly influences how cancer cells survive, spread, and respond to treatment. However, the molecular factors underlying its dysregulation are not fully understoo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f3542ec-7af6-54bc-bc9d-bab4a9762c92
DOI: 10.21203/rs.3.rs-8727350/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Secretome proteomics-based targeting of inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) and clusterin (Clu) mitigates p53 amyloid–mediated tumorigenesis in oral carcinomaDOI 10.21203/rs.3.rs-8727350/v1Read

Mutant p53-Mediated Tumor Secretome: Bridging Tumor Cells and Stromal Cells.Semantic proximity Read

Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulationSemantic proximity Read

Combining discovery and targeted proteomics reveals a prognostic signature in oral cancerSemantic proximity Read

Potential oncogenic roles of mutant-p53-derived exosomes in the tumor-host interaction of head and neck cancers.Semantic proximity Read

Decipher β2-microglobulin: gain- or loss-of-function (a mini-review).Semantic proximity Read

p53 amyloid pathology with cancer grades and p53 mutationsSemantic proximity Read

Secreted protein markers in oral squamous cell carcinoma (OSCC)Semantic proximity Read

Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis.Semantic proximity Read

MMP2 As An Independent Prognostic Stratifier In Oral Cavity CancersSemantic proximity Read

Fibronectin, DHPS and SLC3A2 Signaling Cooperate to Control Tumor Spheroid Growth, Subcellular eIF5A1/2 Distribution and CDK4/6 Inhibitor ResistanceSemantic proximity Read

Exosomal S100A9 Promotes Lung Metastasis of Adenoid Cystic Carcinoma via Activating Cancer-Associated FibroblastsSemantic proximity Read

Secretome Compartment Is a Valuable Source of Biomarkers for Cancer-Relevant PathwaysSemantic proximity Read