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Article

Secretome Compartment Is a Valuable Source of Biomarkers for Cancer-Relevant Pathways

14 Jul 2011

Abstract excerpt

In principle, targeted therapies have optimal activity against a specific subset of tumors that depend upon the targeted molecule or pathway for growth, survival, or metastasis. Consequently, it is important in drug development and clinical practice to have predictive biomarkers that can reliably identify patients who will benefit from a given therapy. We analyzed tumor cell-line secretomes (conditioned cell...

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PMID: 21751813
DOI: 10.1021/pr200344n

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