Article

Metabolomic and Proteomic Analysis of Bone Marrow Supernatant in Myelodysplastic Syndrome Using Astral-based DIA and LC-MS/MS

2025-12-08

Abstract excerpt

<title>Abstract</title> <p>Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem cell disorders characterized by malignant potential and complex pathobiological mechanisms. While specific gene mutations (SF3B1, TET2, ASXL1, TP53) contribute significantly to MDS, disease progression depends equally on malignant clones and the bone marrow microenvironment. We employed integrat...

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Literature Corpus work: 6f1e4851-c6d8-56aa-93ab-d037514c55f6
DOI: 10.21203/rs.3.rs-7572811/v1

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