Article

Integrated Multi-Cohort Analysis of Whole-Genome and Transcriptome Data Reveals Interplay between Metabolism and Methylation in Myelodysplastic Syndrome (MDS)

2024-02-22

Abstract excerpt

<h4>Objectives: </h4> Metabolic interactions amongst mutated genes in myelodysplastic syndrome (MDS) offer promising avenues for novel anticancer treatments. Our comprehensive study delves into these mutational and transcriptomic landscapes, pinpointing hallmark gene mutations and deregulated gene expression that could influence MDS patients’ metabolomes. <h4>Methods:</h4> The study utilized a retrospective, cross...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72b49a90-6633-5a40-bf11-79f1029808b4
DOI: 10.20944/preprints202402.1079.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated Multi-Cohort Analysis of Whole-Genome and Transcriptome Data Reveals Interplay between Metabolism and Methylation in Myelodysplastic Syndrome (MDS)DOI 10.20944/preprints202402.1079.v2Read

Landscape Of Genetic Lesions In 944 Patients With Myelodysplastic SyndromesSemantic proximity Read

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes.Semantic proximity Read

Bibliometric analysis of the Global Myelodysplastic Syndrome Study 1998-2022Semantic proximity Read

Prognostic implications of genetic and transcriptomic abnormalities in MDS according to IPSS-R, IPSS-M, and the International Consensus Classification.Semantic proximity Read

Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets.Semantic proximity Read

Unique epigenomic signatures identify biologically significant subtypes of MDS and predict response to azacitidineSemantic proximity Read

Targeted single-cell RNA sequencing analysis reveals metabolic reprogramming and the ferroptosis-resistant state in hematologic malignancies.Semantic proximity Read

Global research trends in myelodysplastic syndromes drug resistance: A comprehensive bibliometric and knowledge mapping studySemantic proximity Read

Prognostic value of isocitrate dehydrogenase mutations in myelodysplastic syndromes: a retrospective cohort study and meta-analysis.Semantic proximity Read

Implications for metabolic disturbances in myelodysplastic syndromes.Semantic proximity Read

DNA methylation identifies genetically and prognostically distinct subtypes of myelodysplastic syndromesSemantic proximity Read

Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study.Semantic proximity Read