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Article

Regulation of phagolysosomal activity by miR-204 critically influences structure and function of retinal pigment epithelium/retina

13 Jul 2019

Abstract excerpt

MicroRNA-204 (miR-204) is expressed in pulmonary, renal, mammary and eye tissue, and its reduction can result in multiple diseases including cancer. We first generated miR-204-/- mice to study the impact of miR-204 loss on retinal and retinal pigment epithelium (RPE) structure and function. The RPE is fundamentally important for maintaining the health and integrity of the retinal photoreceptors. miR-204-/- eyes...

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PMID: 31332443
DOI: 10.1093/hmg/ddz171

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