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Article

Wnt signaling dysregulation drives Stargardt disease pathogenesis.

Science China. Life sciences - 1 May 2026

Zhang Xiao, Liu Zhuo-Lin, Lin Xiao, Sun Shu-Ning, Shi Dandan, Tian Lu, Li Yang, Jin Zi-Bing

Abstract excerpt

Stargardt disease, the most common inherited juvenile macular degeneration, is primarily caused by ABCA4 mutations, yet the cellular origin of pathology remains debated. Here, we identify a critical role for Wnt signaling dysregulation, specifically non-canonical Wnt pathway suppression, in driving retinal pigment epithelium (RPE) dysfunction as a central mechanism of disease. Using patient-derived iPSC-RPE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41701438
DOI: 10.1007/s11427-025-3184-y

Genes

ABCA4
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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