Article
Inherited cardiac diseases caused by mutations in the Nav1.5 sodium channel.
Journal of cardiovascular electrophysiology - 1 Jan 2010
Tfelt-Hansen Jacob, Winkel Bo Gregers, Grunnet Morten, Jespersen Thomas
Abstract excerpt
A prerequisite for a normal cardiac function is a proper generation and propagation of electrical impulses. Contraction of the heart is obtained through a delicate matched transmission of the electrical impulses. A pivotal element of the impulse propagation is the depolarizing sodium current, responsible for the initial depolarization of the cardiomyocytes. Recent research has shown that mutations in the SCN5A...
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