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Covalent Probes To Capture Legionella pneumophila Dup Effector Enzymes

17 Sept 2024

Abstract excerpt

releases a multitude of effector enzymes into the cell's cytoplasm that hijack a plethora of cellular activities, including the host ubiquitination pathways. Effectors belonging to the SidE-family are involved in noncanonical serine phosphoribosyl ubiquitination of host substrate proteins contributing to the formation of a Legionella-containing vacuole that is crucial in the onset of Legionnaires' disease. This...

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PMID: 39288007
DOI: 10.1021/jacs.4c08168

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