Article

A Translational Preclinical Strategy for Chronic Spinal Cord Injury: Neuroprotective and Regenerative Potential of Botulinum Neurotoxin Type A combined with Muscle Atrophy Prevention via Electrostimulation

2026-03-25

Abstract excerpt

<h4>Background</h4> Spinal cord injury (SCI) triggers persistent neuroinflammation, gliosis, neuronal loss, and demyelination, leading to motor deficits and neuropathic pain. Botulinum neurotoxin type A (BoNT/A) has shown anti-inflammatory and neuroprotective effects in acute SCI, but its potential in the chronic phase remains unclear. This study investigates whether combining BoNT/A with electrical muscle stimul...

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Literature Corpus work: a2134bce-db8b-52a6-96a5-98d2019c93d6
DOI: 10.64898/2026.03.23.713625

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