Article

Targeting Neuromuscular Junction Regeneration is a Therapeutic Strategy in ALS

2025-07-17

Abstract excerpt

Instability and denervation of the neuromuscular junction (NMJ) are early events in Amyotrophic Lateral Sclerosis (ALS), likely reflecting a progressive decline in the regenerative capacity of motor neurons (MNs) and their environment. To investigate this, we evaluated NMJ regeneration throughout disease progression in SOD1 G93A mice following reversible axon terminal degeneration induced by α-Latrotoxin. In para...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 209ad4cf-168d-5548-b46b-c159259fbab8
DOI: 10.1101/2025.07.13.664600

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Neuromuscular Junction Regeneration is a Therapeutic Strategy in ALSDOI 10.1101/2025.07.13.664600Read

Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS miceSemantic proximity Read

Integrin-driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration ProgramSemantic proximity Read

Rapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathySemantic proximity Read

Skeletal muscle dysfunction in amyotrophic lateral sclerosis: a mitochondrial perspective and therapeutic approachesSemantic proximity Read

Enhanced axonal regeneration of ALS patient iPSC-derived motor neurons harboring SOD1A4V mutation.Semantic proximity Read

Recent progress and challenges in the treatment of spinal cord injurySemantic proximity Read

NOX4 inhibition promotes the remodeling of dystrophic muscleSemantic proximity Read

Single Cell Deconstruction of Muscle Stem Cell Heterogeneity During Aging Reveals Sensitivity to the Neuromuscular JunctionSemantic proximity Read

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.Semantic proximity Read

Hypoimmunogenic human motor neurons induced from iPSCs in vivo substantially ameliorate ALS disease in large animal modelsSemantic proximity Read

Single-cell RNA sequencing reveals the role of immune-related autophagy in spinal cord injury in ratsSemantic proximity Read

GDNF levels regulate lumbar motor neuron physiology and determine life expectancy in limb-onset ALSSemantic proximity Read