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How is the Amyloid Fold Built? Polymorphism and the Microscopic Mechanisms of Fibril Assembly

13 Feb 2025

Abstract excerpt

• How fibril polymorphism is linked to assembly mechanisms is a key question. • Kinetic models of fibril assembly were adapted to include polymorphism. • Marrying kinetic models to structural detail will deconvolute structural polymorphism. • This will help us to understand differences between in vitro vs in vivo structures. For a given protein sequence, many, up to sometimes hundreds of different amyloid fibril...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 39954780
DOI: 10.1016/j.jmb.2025.169008

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