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Article

GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation.

Translational psychiatry - 18 Dec 2024

Tong Jia, Gao Jingjing, Qi Yawei, Gao Ziyan, Wang Qianqian, Liu Yang, Yuan Tiangang, Ren Minglong, Yang Guixia, Li Zhaoyue, Li Jin, Sun Hongyuan, Zhao Xing, Leung Yeung-Yeung, Mu Yonghui, Xu Jiamin, Lu Chengbiao, Peng Shiyong, Ge Lihao

Abstract excerpt

The infantile neuronal ceroid lipofuscinosis, also called CLN1 disease, is a fatal neurodegenerative disease caused by mutations in the CLN1 gene encoding palmitoyl protein thioesterase 1 (PPT1). Identifying the depalmitoylation substrates of PPT1 is crucial for understanding CLN1 disease. In this study, we found that GABAAR, the critical synaptic protein essential for inhibitory neurotransmission, is a substrate...

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Identifiers

PMID: 39695089
DOI: 10.1038/s41398-024-03206-1
PMCID: PMC11655527

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