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Article

In a mouse model of INCL reduced S-palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation.

Journal of inherited metabolic disease - 1 Jul 2021

Sadhukhan Tamal, Bagh Maria B, Appu Abhilash P, Mondal Avisek, Zhang Wei, Liu Aiyi, Mukherjee Anil B

Abstract excerpt

S-palmitoylation is a reversible posttranslational modification in which a 16-carbon saturated fatty acid (generally palmitate) is attached to specific cysteine residues in polypeptides via thioester linkage. Dynamic S-palmitoylation (palmitoylation-depalmitoylation), like phosphorylation-dephosphorylation, regulates the function of numerous proteins, especially in the brain. While a family of 23 palmitoyl-acyl...

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PMID: 33739454
DOI: 10.1002/jimd.12379

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