Article

GABA <sub>A</sub> R-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation in CLN1 disease

2024-03-29

Abstract excerpt

<h4>Summary</h4> CLN1 disease, also called infantile neuronal ceroid lipofuscinosis, is a fatal neurodegenerative disease caused by mutations in the CLN1 gene encoding palmitoyl protein thioesterase 1 (PPT1). To identify depalmitoylation substrate of PPT1 is crucial to understand CLN1 disease. In this study, we found that PPT1 depalmitoylates GABA A R α1 subunit at Cystein-260, while binding to Cystein-165 and −...

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Literature Corpus work: 05cfb4b4-310f-5c58-aa14-70a826fc6786
DOI: 10.1101/2024.03.26.585929

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