Article
Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation.
Nature neuroscience - 1 Jul 2009
Lin Da-Ting, Makino Yuichi, Sharma Kamal, Hayashi Takashi, Neve Rachael, Takamiya Kogo, Huganir Richard L
Abstract excerpt
The insertion of AMPA receptors (AMPARs) into the plasma membrane is an important step in the synaptic delivery of AMPARs during the expression of synaptic plasticity. However, the molecular mechanisms regulating AMPAR insertion remain elusive. By directly visualizing individual insertion events of the AMPAR subunit GluR1 in rodents, we found that the protein 4.1N was required for activity-dependent GluR1...
Topics
- Animals
- Cell Membrane
- Cells, Cultured
- Cytoskeletal Proteins
- Hippocampus
- In Vitro Techniques
- Lipoylation
- Long-Term Potentiation
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Microscopy, Fluorescence
- Mutation
- Neurons