Article

Inhibition of Yes-Associated Protein (YAP) with Verteporfin Enhances Radiosensitivity in Chordoma by Inducing G <sub>2</sub> M Arrest and Inhibiting the DNA Damage Response

2024-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Chordomas are locally invasive cancers that are highly resistant to radiotherapy. The Brachyury and Yes-Associated Protein (YAP) regulatory axis has been implicated as the primary driver of tumorigenicity in chordoma. Here, we aimed to enhance chordoma radiosensitivity by repurposing the FDA-approved YAP inhibitor, Verteporfin. We used five patient-derived chordoma cell lines and generated two Y...

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Literature Corpus work: 6e1d4c94-3c88-5005-97fe-ffd6ce0c169c
DOI: 10.1101/2024.11.03.621728

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Inhibition of Yes-Associated Protein (YAP) with Verteporfin Enhances Radiosensitivity in Chordoma by Inducing G <sub>2</sub> M Arrest and Inhibiting the DNA Damage ResponseDOI 10.1101/2024.11.03.621728Read

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