Article
Chemotherapy of skull base chordoma tailored on responsiveness of patient-derived tumor cells to rapamycin.
Neoplasia (New York, N.Y.) - 1 Jul 2013
Ricci-Vitiani Lucia, Runci Daniele, D'Alessandris Quintino Giorgio, Cenci Tonia, Martini Maurizio, Bianchi Federico, Maira Giulio, Stancato Louis, De Maria Ruggero, Larocca Luigi Maria, Pallini Roberto
Abstract excerpt
Skull base chordomas are challenging tumors due to their deep surgical location and resistance to conventional radiotherapy. Chemotherapy plays a marginal role in the treatment of chordoma resulting from lack of preclinical models due to the difficulty in establishing tumor cell lines and valuable in vivo models. Here, we established a cell line from a recurrent clival chordoma. Cells were cultured for more than...
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