Article
Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy.
Neoplasia (New York, N.Y.) - 1 Nov 2017
Harryman William L, Gard Jaime M C, Pond Kelvin W, Simpson Skyler J, Heppner Lucas H, Hernandez-Cortes Daniel, Little Andrew S, Eschbacher Jennifer M, Cress Anne E
Abstract excerpt
Chordoma is a rare, radiation-resistant, skull-base and spinal tumor with high local recurrence containing mixed cell-adhesion phenotypes. We characterized DNA damage response (DDR) signaling (γH2AX, pKAP1, pATM) and survival response to ionizing radiation (IR) in human chordoma samples (42 resections, 23 patients) to test if blocking cell adhesion sensitizes U-CH1 tumor cells to IR. U-CH1 cells expressed...
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