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Article

Mammalian target of rapamycin complex 1 signalling is essential for germinal centre reaction.

Immunology - 1 Oct 2017

Li Bingshou, Li Zhirong, Wang Pengcheng, Huang Qizhao, Xu Lifan, He Ran, Ye Lilin, Bai Qiang

Abstract excerpt

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that has been shown to be essential for the differentiation and function of various immune cells. Earlier in vitro studies showed that mTOR signalling regulates B-cell biology by supporting their activation and proliferation. However, how mTOR signalling temporally regulates in vivo germinal centre B (GCB) cell development and differentiation...

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Share to Germinal Center
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28557002
DOI: 10.1111/imm.12767
PMCID: PMC5588811

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