Article
Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2010
Carayol Nathalie, Vakana Eliza, Sassano Antonella, Kaur Surinder, Goussetis Dennis J, Glaser Heather, Druker Brian J, Donato Nicholas J, Altman Jessica K, Barr Sharon, Platanias Leonidas C
Abstract excerpt
mTOR-generated signals play critical roles in growth of leukemic cells by controlling mRNA translation of genes that promote mitogenic responses. Despite extensive work on the functional relevance of rapamycin-sensitive mTORC1 complexes, much less is known on the roles of rapamycin-insensitive (RI) complexes, including mTORC2 and RI-mTORC1, in BCR-ABL-leukemogenesis. We provide evidence for the presence of mTORC2...
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