Article

Targeting the mTORC2 signaling complex in B cell malignancies

2019-03-05

Abstract excerpt

Hyperactive PI3 kinase-Akt (PI3K-Akt) signaling has an important role in cell growth and resistance to apoptosis in B cell malignancies. Inhibition of this pathway by blocking PI3K activity, and or inhibiting mTORC1/2 signaling complexes is an active area of research in B cell leukemia/lymphoma such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). With a tissue-scan array, the expression of Ri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4792a4d0-21b3-5045-aa9d-366a7eaeab11
DOI: 10.1101/564500

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting the mTORC2 signaling complex in B cell malignanciesDOI 10.1101/564500Read

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells.Semantic proximity Read

Targeting the mTOR Pathway in LeukemiaSemantic proximity Read

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancerSemantic proximity Read

Predominance of mTORC1 over mTORC2 in the Regulation of Proliferation of Ovarian Cancer Cells: Therapeutic ImplicationsSemantic proximity Read

mTORC1 activity is essential for disease progression in chronic lymphocytic leukemiaSemantic proximity Read

Will targeting PI3K/Akt/mTOR signaling work in hematopoietic malignancies?Semantic proximity Read

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivationSemantic proximity Read

Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancerSemantic proximity Read

Recent development in targeting PI3K-Akt-mTOR signaling for anticancer therapeutic strategies.Semantic proximity Read

Targeting mTOR in Acute Lymphoblastic LeukemiaSemantic proximity Read

Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemiaSemantic proximity Read

[he importance of mTOR hyperactivity and RICTOR amplification, and the associated targeted therapy possibilities in malignant tumours].Semantic proximity Read