Article

Distinct Retrotransposon Transcriptome in Pediatric Crohn’s Disease

2025-04-22

Abstract excerpt

<h4>Background and Aims</h4> Crohn’s disease (CD) is an autoimmune condition with inflammation of the gastrointestinal tract. The etiology of CD is complex with underlying mechanisms only partially elucidated. Retrotransposons, a category of transposable elements within a genome, have been shown to contribute to the pathogenesis of inflammatory and autoimmune disorders. This research aimed to explore the expressio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e111397-0c7a-5c36-b594-46ae53e354e7
DOI: 10.1101/2025.04.21.25326010

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct Retrotransposon Transcriptome in Pediatric Crohn’s DiseaseDOI 10.1101/2025.04.21.25326010Read

Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn’s Disease PatientsSemantic proximity Read

Profiling Non-Coding RNA Levels With Clinical Classifiers in Pediatric Crohn’s DiseaseSemantic proximity Read

Multi-ancestry genome-wide and transcriptome-wide association analyses identified new risk loci and genes for inflammatory bowel diseaseSemantic proximity Read

A collection of patient-derived intestinal organoid lines reveals epithelial pheno-types associated with genetic drivers of pediatric inflammatory bowel diseaseSemantic proximity Read

Spatial host-microbiome profiling demonstrates bacterial-associated host transcriptional alterations in pediatric ileal Crohn’s diseaseSemantic proximity Read

Integration of single-cell transcriptome and genetic profiles reveals critical cell types and genes in inflammatory bowel diseaseSemantic proximity Read

Genomic Insights into Pediatric Intestinal Inflammatory and Eosinophilic Disorders using Single-sell RNA-sequencingSemantic proximity Read

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s DiseaseSemantic proximity Read

Enhanced Transcription of Human Endogenous Retroviruses and TRIM28 Downregulation in Patients with Inflammatory Bowel DiseaseSemantic proximity Read

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn’s Disease PathogenesisSemantic proximity Read

Understanding the link between regulatory RNA regions and genomic variation in coeliac disease.Semantic proximity Read

Dissecting the mechanisms of intestinal immune homeostasis by analyzing T-cell immune response in Crohn's disease and colorectal cancerSemantic proximity Read