Article

Localgini: A method for harnessing inequality in gene expression to improve the quality of context-specific models

2023-09-17

Abstract excerpt

Genome-scale metabolic models (GEMs) are valuable tools for investigating normal and disease phenotypes of biological systems through the prediction of fluxes in biochemical reactions. However, in specific contexts such as different cell lines, tissues, or diseases, only a subset of reactions is active. To address this, several model extraction methods (MeMs) have been developed to filter the reactions in GEMs and...

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Literature Corpus work: 6df80767-033b-581b-9eeb-8b382d328260
DOI: 10.1101/2023.09.14.557840

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