Article

Ketamine blocks morphine-induced conditioned place preference and anxiety-like behaviors in mice

2020-01-23

Abstract excerpt

Patients suffering from opioid use disorder often relapse during periods of abstinence, which is posited to be caused by negative affective states that drive motivated behaviors. Here, we explored whether conditioning mice with morphine in a CPP training paradigm evoked anxietylike behavior during morphine abstinence. To do this, mice were conditioned with morphine (10 mg/kg, i.p.) for five days. 24 h following co...

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Literature Corpus work: 6df6d66c-90b3-58ff-b1f3-a3e9db657481
DOI: 10.1101/2020.01.22.915728

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