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Article

Per- and polyfluoroalkyl substances and kidney disease: Genetic associations and computational prioritization of candidate toxicogenomic pathways.

PLoS computational biology - 1 Sept 2026

Zeng Dianjie, Wang Yuxi, Wang Yinhuai, Li Guoqiang, Wang Wenpeng, Zuo Zhongkun

Abstract excerpt

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants with bioaccumulation potential, but their associations with kidney diseases remain incompletely understood. This study integrated Mendelian randomization and computational toxicology to examine associations between genetically predicted circulating PFAS levels and kidney disease outcomes and to prioritize candidate toxicogenomic...

Read the complete abstract on PubMed

Topics

Humans
Fluorocarbons
Kidney Diseases
Environmental Pollutants
Computational Biology
Toxicogenetics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Genetic Predisposition to Disease

Alkanesulfonic Acids

Source

Open in PubMed Open full text

Identifiers

PMID: 42752549
DOI: 10.1371/journal.pcbi.1014665
PMCID: PMC13596822

Genes

PFAS
CCL2
CTNNB1
EGFR
IFNG
IGF1
IL1B
IL6
MMP9
TLR4
TNF
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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