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Article

Gut Microbiota Signatures and Potential Mediators in the Trajectory of Age-related Macular Degeneration: A Phased Atlas by Genetic Inference.

International journal of medical sciences - 1 Jan 2026

Zhou Yifan, Wang Zhenyu, Huang Chen, Yu Xiaotong, Chen Junfu, Jiang Xinhao, Dong Jialong, Peng Qing, Li Long, Song Xudong, Lu Xinmin

Abstract excerpt

Purpose: To depict an atlas of stage-stratified gut microbiota (GM) signatures and intermediatory metabolites, inflammatory proteins, and immune cell traits, governing the AMD trajectory. Methods: We deployed bidirectional two-sample Mendelian randomization (TSMR) integrating GWAS data of 207 GM taxa from the Dutch Microbiome Project (N = 7,738), and multiple AMD stages/subtypes, including 'Macular degeneration...

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Identifiers

PMID: 41799763
DOI: 10.7150/ijms.119158
PMCID: PMC12964563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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