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Fecal Microbial Profiles and Short-Chain Fatty Acid/Bile Acid Metabolomics in Patients With Age-Related Macular Degeneration: A Pilot Study.

Investigative ophthalmology & visual science - 1 Apr 2025

Parekh Zaid, Xiao Jason, Mani Amir, Evans Quadis, Phung Christopher, Barba Hugo A, Xie Bingqing, Sidebottom Ashley M, Sundararajan Anitha, Lin Huaiying, Ramaswamy Ramanujam, Dao David, Gonnah Reem, Yehia Madeleine, Hariprasad Seenu M, D'Souza Mark, Sulakhe Dinanath, Chang Eugene B, Skondra Dimitra

Abstract excerpt

Purpose: Age-related macular degeneration (AMD) is a multifactorial disease, and studies have implicated the role of gut microbiota in its pathogenesis. However, characterization of microbiome dysbiosis and associated microbial-derived metabolomic profiles across AMD stages remains unknown. In this pilot study, we explored how gut microbiome composition and gut-derived metabolites differ in AMD. Methods: Our...

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Identifiers

PMID: 40202735
DOI: 10.1167/iovs.66.4.21
PMCID: PMC11993127

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