Developing mouse complex I as a model system : structure, function and implications in mitochondrial diseases

Abstract excerpt

Complex I (NADH:ubiquinone oxidoreductase), located in the mitochondrial inner membrane, is a major electron entry point to the respiratory chain. It couples the energy released from electron transfer (from NADH to ubiquinone) to the concomitant pumping of protons across the membrane, to generate an electrochemical proton motive force. Mammalian complex I is composed of 45 subunits, 14 of which comprise its simple...

Topics

Open a Topic to create a Post that cites this publication.

• Cryoelectron Microscopy
• Electron Transport Complex I
• Mice
• Mice, Knockout
• Mitochondrial Diseases
• Mutation
• NADH Dehydrogenase
• Protein Conformation

Identifiers and source

Literature Corpus work

6d983ae4-ea67-5e01-ac1e-1ecca91638e3

DOI

10.17863/cam.30568