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Mammalian Mitochondrial Complex I Structure and Disease-Causing Mutations.

Trends in cell biology - 1 Oct 2018

Fiedorczuk Karol, Sazanov Leonid A

Abstract excerpt

Complex I has an essential role in ATP production by coupling electron transfer from NADH to quinone with translocation of protons across the inner mitochondrial membrane. Isolated complex I deficiency is a frequent cause of mitochondrial inherited diseases. Complex I has also been implicated in cancer, ageing, and neurodegenerative conditions. Until recently, the understanding of complex I deficiency on the...

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PMID: 30055843
DOI: 10.1016/j.tcb.2018.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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