Article

Using molecular approaches to understand Complex I deficiency in mouse models

2021-01-01

Abstract excerpt

Complex I (NADH:ubiquinone oxidoreductase), a major electron entry point to the mitochondrial respiratory chain, couples electron transfer from NADH to ubiquinone to proton pumping across the mitochondrial inner membrane, and generates the proton motive force that drives ATP synthesis and transport processes. The ~1 MDa mammalian complex contains 45 subunits, and pathological mutations in both its mitochondrial an...

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Literature Corpus work: 5e54141c-39e7-564c-b563-c01aff6942bf
DOI: 10.17863/cam.71405

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