The combined impact of HLA and non-HLA mismatch between donors and recipients on kidney transplant survival: a genomic analysis in a prospective cohort.

doi:10.1016/j.ebiom.2026.106420

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Article

The combined impact of HLA and non-HLA mismatch between donors and recipients on kidney transplant survival: a genomic analysis in a prospective cohort.

EBioMedicine - 1 Sept 2026

Kammer Michael, Heinzel Andreas, Shoebridge Stephen, Reindl-Schwaighofer Roman, Hu Karin, Chen Hao Shan, Kainz Alexander, Daoudi Ismail, David Ana F, Fischer Gottfried, Keating Brendan, Niemann Matthias, Oberbauer Rainer

Abstract excerpt

BACKGROUND: Kidney transplantation outcomes are strongly influenced by immunological compatibility between donor and recipient. While genetic mismatches in the human leukocyte antigen (HLA) region have long been recognised as key determinants of graft survival, increasing evidence, including our own previous work, suggests that non-HLA alloimmunity also plays a critical role. METHODS: We sequenced exomes of...

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Topics

Humans
Kidney Transplantation
Female
Graft Survival
HLA Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Tissue Donors

Polymorphism, Single Nucleotide

Middle Aged

Prospective Studies

Genomics

Adult

Histocompatibility Testing

Graft Rejection

Transplant Recipients

Histocompatibility

Proportional Hazards Models

Source

Open in PubMed Open full text

Identifiers

PMID: 42556135
DOI: 10.1016/j.ebiom.2026.106420
PMCID: PMC13471318

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