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Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease

19 Dec 2021

Abstract excerpt

Huntington's disease is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in ageing humans. To address this, we generated induced neurons through direct reprogramming of human skin fibroblasts, which retain age-dependent epigenetic characteristics. Huntington's...

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PMID: 34936701
DOI: 10.1093/brain/awab473

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