Article

Intercellular Transfer of PTBP1 Drives Human Neural Stem Cell Fate

2026-02-20

Abstract excerpt

During fetal brain development, temporally defined alternative splicing (AS) programs control human neural stem cell (hNSC) self-renewal and differentiation, thereby regulating neurogenesis and gliogenesis. Polypyrimidine tract-binding protein 1 (PTBP1) is a master regulator of AS during neurogenesis; however, its functional role and dynamics in hNSCs remain largely unexplored. Here, we investigate the cellular an...

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Literature Corpus work: 6d75f670-7792-53d3-8fb6-e43df42edff1
DOI: 10.64898/2026.02.19.706765

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