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Article

Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor.

Structure (London, England : 1993) - 1 Jul 2021

Smit Florent X, van der Velden Wijnand J C, Kizilkaya Hüsün S, Nørskov Amalie, Lückmann Michael, Hansen Tobias N, Sparre-Ulrich Alexander H, Qvotrup Katrine, Frimurer Thomas M, Rosenkilde Mette M

Abstract excerpt

The glucose-dependent insulinotropic polypeptide (GIP) is a 42-residue metabolic hormone that is actively being targeted for its regulatory role of glycemia and energy balance. Limited structural data of its receptor has made ligand design tedious. This study investigates the structure and function of the GIP receptor (GIPR), using a homology model based on the GLP-1 receptor. Molecular dynamics combined with...

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Identifiers

PMID: 33891864
DOI: 10.1016/j.str.2021.04.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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