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Article

Hemoglobin stimulates vigorous growth of Streptococcus pneumoniae and shapes the pathogen's global transcriptome.

Scientific reports - 16 Sept 2020

Akhter Fahmina, Womack Edroyal, Vidal Jorge E, Le Breton Yoann, McIver Kevin S, Pawar Shrikant, Eichenbaum Zehava

Abstract excerpt

Streptococcus pneumoniae (Spn) must acquire iron from the host to establish infection. We examined the impact of hemoglobin, the largest iron reservoir in the body, on pneumococcal physiology. Supplementation with hemoglobin allowed Spn to resume growth in an iron-deplete medium. Pneumococcal growth with hemoglobin was unusually robust, exhibiting a prolonged logarithmic growth, higher biomass, and extended...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32938947
DOI: 10.1038/s41598-020-71910-1
PMCID: PMC7494912

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