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Endogenously produced H 2 O 2 is intimately involved in iron metabolism in Streptococcus pneumoniae

1 Dec 2023

Abstract excerpt

ABSTRACT In the presence of molecular oxygen, the human pathogen Streptococcus pneumoniae produces and secretes large amounts of hydrogen peroxide (H 2 O 2 ), which can readily interact with free and heme-bound iron. Here, we investigated the role of the endogenously produced H 2 O 2 in iron acquisition. The data revealed that S. pneumoniae uses H 2 O 2 to liberate iron from met-hemoglobin (Hb-Fe 3+ )...

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Identifiers

PMID: 38038454
DOI: 10.1128/spectrum.03297-23

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