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Article

The crimson conundrum: heme toxicity and tolerance in GAS.

Frontiers in cellular and infection microbiology - 1 Jan 2014

Sachla Ankita J, Le Breton Yoann, Akhter Fahmina, McIver Kevin S, Eichenbaum Zehava

Abstract excerpt

The massive erythrocyte lysis caused by the Group A Streptococcus (GAS) suggests that the β-hemolytic pathogen is likely to encounter free heme during the course of infection. In this study, we investigated GAS mechanisms for heme sensing and tolerance. We compared the minimal inhibitory concentration of heme among several isolates and established that excess heme is bacteriostatic and exposure to sub-lethal...

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Identifiers

PMID: 25414836
DOI: 10.3389/fcimb.2014.00159
PMCID: PMC4220732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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