Article

Single-cell spatial multi-omic characterization of the tumour microenvironment in transformed follicular lymphoma

2026-08-15

Abstract excerpt

Histological examination of follicular lymphoma (FL) biopsies remains the cornerstone for diagnostic grading of FL. Single-cell sequencing approaches, while transcriptomically rich, require tissue dissociation and lose the native spatial context that underpins FL transformation to diffuse large B-cell lymphoma (DLBCL). To investigate the spatial interplay between malignant B-cells and the tumour microenvironment (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d6224a8-6318-5691-afd6-ad379179270c
DOI: 10.64898/2026.08.11.743383

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell spatial multi-omic characterization of the tumour microenvironment in transformed follicular lymphomaDOI 10.64898/2026.08.11.743383Read

Integrated single cell analysis reveals co-evolution of malignant B cells and the tumor microenvironment in transformed follicular lymphomaSemantic proximity Read

Distinct follicular T cell subsets regulate lymphoma progression and outcomesSemantic proximity Read

Advances in the multi-omics landscape of follicular lymphomaSemantic proximity Read

Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic targetSemantic proximity Read

<i>PD-L1</i> –linked spatial decoupling of tumour–immune interactions in EBV-positive DLBCLSemantic proximity Read

Unraveling transformation of follicular lymphoma to diffuse large B-cell lymphomaSemantic proximity Read

Spatial Proteomics Reveals Dual-Compartment Immune Evasion Architecture and Core Lymphomagenic Stromal Niches in Follicular LymphomaSemantic proximity Read

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.Semantic proximity Read

A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph NodesSemantic proximity Read

An updated understanding of follicular lymphoma transformationSemantic proximity Read

The follicular lymphoma epigenome regulates its microenvironment.Semantic proximity Read

Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma.Semantic proximity Read