Article

<i>PD-L1</i> –linked spatial decoupling of tumour–immune interactions in EBV-positive DLBCL

2026-07-04

Abstract excerpt

EBV-positive diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma enriched in elderly patients, in which PD-L1 genomic gains cooperate with viral signalling to promote immune escape. However, the spatial mechanisms by which PD-L1 reshapes the tumour microenvironment remain unresolved. Here, we integrate genomic profiling with spatial transcriptomics, spatial proteomics, and single-cell RNA sequencing...

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Literature Corpus work: b8160dc5-b008-53b8-9f68-6ef0303e1ad8
DOI: 10.64898/2026.07.02.26357123

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