Article

Discovery of miRNA–RNA Biomarkers for Risk Stratification in Acute Myeloid Leukemia with Multi-Cohort Validation

2025-12-01

Abstract excerpt

Acute myeloid leukemia (AML) is a clinically aggressive and molecularly heterogeneous malignancy. Current prognostic standards, such as the European LeukemiaNet (ELN) classification, do not fully capture its regulatory complexity. We developed a two-step, PCA-based survival workflow that independently and jointly models gene and miRNA expression to identify biomarkers for patient risk stratification, followed by s...

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Literature Corpus work: 41e975e6-dc92-5c18-b71b-5ce8d7686447
DOI: 10.1101/2025.11.26.690852

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