Article

Addressing the Global Diagnostics Gap for Childhood Leukemias: A Global, Multisite Type 2 Hybrid Validation Study of Nanopore-based Adaptive Sampling Whole Genome Sequencing

2026-05-21

Abstract excerpt

<h4>Background</h4> Modern therapy for childhood and adolescent leukemia requires accurate risk classification of genomic subtype. Although short-read next-generation sequencing (NGS)-based approaches provide comprehensive clinical diagnostics in limited, highly resourced settings, they remain expensive, slow, and inaccessible to most children worldwide. Transformative approaches are needed to improve diagnostic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d4c77d7-0510-571d-9b37-7c98e0875461
DOI: 10.64898/2026.05.19.26353434

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Addressing the Global Diagnostics Gap for Childhood Leukemias: A Global, Multisite Type 2 Hybrid Validation Study of Nanopore-based Adaptive Sampling Whole Genome SequencingDOI 10.64898/2026.05.19.26353434Read

Real-time genomic characterization of pediatric acute leukemia using adaptive samplingSemantic proximity Read

Technical Validation and Clinical Utility of an NGS Targeted Panel to Improve Molecular Characterization of Pediatric Acute LeukemiaSemantic proximity Read

Real-time genomic characterization of pediatric acute leukemia using adaptive samplingSemantic proximity Read

Genome profiling with targeted adaptive sampling long-read sequencing for pediatric leukemiaSemantic proximity Read

Single-workflow Nanopore whole genome sequencing with adaptive sampling for accelerated and comprehensive pediatric cancer profilingSemantic proximity Read

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemiaSemantic proximity Read

Design and Validation of a Custom Next-Generation Sequencing Panel in Pediatric Acute Lymphoblastic Leukemia.Semantic proximity Read

Multi-cohort transcriptomic subtyping of B-cell acute lymphoblastic leukemiaSemantic proximity Read

Ultrarapid Targeted Nanopore Sequencing for Fusion Detection of LeukemiasSemantic proximity Read

SJPedPanel: A pan-cancer gene panel for childhood malignanciesSemantic proximity Read

Clinical experience of using integrated whole genome and transcriptome sequencing as a framework for pediatric and adolescent acute myeloid leukemia diagnosis and risk assessment.Semantic proximity Read

A Study Protocol for Validation and Implementation of Whole-Genome and -Transcriptome Sequencing as a Comprehensive Precision Diagnostic Test in Acute LeukemiasSemantic proximity Read