Article

Overcoming bias in gene-set enrichment analyses of brain-wide transcriptomic data

2020-04-25

Abstract excerpt

The recent availability of whole-brain atlases of gene expression, which quantify the transcriptional activity of thousands of genes across many different brain regions, has opened new opportunities to understand how gene-expression patterns relate to spatially varying properties of brain structure and function. To aid interpretation of a given neural phenotype, gene-set enrichment analysis (GSEA) has become a sta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d41f1e1-d7df-5acc-ae40-146c715d5ff5
DOI: 10.1101/2020.04.24.058958

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overcoming bias in gene-set enrichment analyses of brain-wide transcriptomic dataDOI 10.1101/2020.04.24.058958Read

BrainEnrich: Revealing Biological Insights for Imaging-Derived Phenotypes Through Transcriptomic Enrichment.Semantic proximity Read

A practical guide to linking brain-wide gene expression and neuroimaging dataSemantic proximity Read

Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brainSemantic proximity Read

BrainBeacon: A Cross-Species Foundation Model for Single-cell Resolved Brain Spatial TranscriptomicsSemantic proximity Read

Network enrichment significance testing in brain-phenotype association studies.Semantic proximity Read

Deciphering cell type-specific causal genetic effects on brain imaging-derived phenotypes and disorders with single-cell Mendelian randomization.Semantic proximity Read

Expression weighted cell type enrichments reveal genetic and cellular nature of major brain disordersSemantic proximity Read

Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical ApplicationSemantic proximity Read

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathwaysSemantic proximity Read

Resource: A Curated Database of Brain-Related Functional Gene Sets (Brain.GMT)Semantic proximity Read

Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seqSemantic proximity Read

Evolutionary conservation and divergence of human brain co-expression networksSemantic proximity Read