Article
Network enrichment significance testing in brain-phenotype association studies.
Human brain mapping - 1 Jun 2024
Weinstein Sarah M, Vandekar Simon N, Li Bin, Alexander-Bloch Aaron F, Raznahan Armin, Li Mingyao, Gur Raquel E, Gur Ruben C, Roalf David R, Park Min Tae M, Chakravarty Mallar, Baller Erica B, Linn Kristin A, Satterthwaite Theodore D, Shinohara Russell T
Abstract excerpt
Functional networks often guide our interpretation of spatial maps of brain-phenotype associations. However, methods for assessing enrichment of associations within networks of interest have varied in terms of both scientific rigor and underlying assumptions. While some approaches have relied on subjective interpretations, others have made unrealistic assumptions about spatial properties of imaging data, leading...
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