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Article

Role of LFA-1 and ICAM-1 in Cancer

3 Nov 2017

Abstract excerpt

β₂), is just one of many integrins in the human body, but its significance is derived from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (or CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We consider how LFA-1 mediates the interaction of leukocytes with tumors and the role of ICAM-1 in tumor...

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PMID: 29099772
DOI: 10.3390/cancers9110153

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