Article
MAGI3 negatively regulates Wnt/β-catenin signaling and suppresses malignant phenotypes of glioma cells.
Oncotarget - 3 Nov 2015
Ma Qian, Yang Ying, Feng Duiping, Zheng Shuai, Meng Ran, Fa Pengyan, Zhao Chunjuan, Liu Hua, Song Ran, Tao Tao, Yang Longyan, Dai Jie, Wang Songlin, Jiang Wen G, He Junqi
Abstract excerpt
Gliomas are the most common primary brain malignancies and are associated with a poor prognosis. Here, we showed that the PDZ domain-containing protein membrane-associated guanylate kinase inverted 3 (MAGI3) was downregulated at the both mRNA and protein levels in human glioma samples. MAGI3 inhibited proliferation, migration, and cell cycle progression of glioma cells in its overexpression and knockdown studies....
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