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Article

Alterations of Plasma Metabolites Associated with Sickle Cell Trait.

Clinical journal of the American Society of Nephrology : CJASN - 1 Jul 2026

Cai Yanwei, Surapaneni Aditya, Vasconcelos Ana Gabriela, Johnson Mari, Hsu Li, Sun Wei, Kooperberg Charles, Yu Bing, Yeo Wan-Jin, Auer Paul L, Grams Morgan E, Franceschini Nora, Raffield Laura M, Reiner Alex P

Abstract excerpt

KEY POINTS: We identified 69 plasma metabolites associated with sickle cell trait, including markers of eGFR and/or related to oxidative stress pathways. Twenty-five percent or 39% of the sickle cell trait-associated metabolites were replicated in the Atherosclerosis Risk in Communities study. Sickle cell trait-associated metabolites individually or in aggregate were associated with better prediction of incident...

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Biomarkers
Black or African American
Case-Control Studies
Glomerular Filtration Rate
Kidney Failure, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidative Stress

Sickle Cell Trait

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Open in PubMed Open full text

Identifiers

PMID: 41758580
DOI: 10.2215/CJN.0000001015
PMCID: PMC13283685

Genes

SCT
SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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