Article

Metabolomic Changes in Idiopathic and <i>GBA1</i> Parkinson’s Disease

2025-09-12

Abstract excerpt

<h4>Background</h4> Variants in the β-glucocerebrosidase ( GBA1 ) gene are the commonest genetic risk factor for Parkinson Disease (PD). Here, we use mass spectrometry based metabolomics to analyse serum and sebum samples from 50 genotyped participants and find differences in lipid and sugar regulation, oxidative stress and the production of amino acids and neurotransmitters which distinguish GBA1 -PD from iPD....

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Literature Corpus work: 6ca99407-ae05-5aed-bb02-de1405e5af72
DOI: 10.1101/2025.09.08.25335343

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