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Mutations in the <i>GBA1</i> , <i>LRRK2</i> , <i>TMEM175</i> , <i>PARK2</i> , <i>PINK1</i> , and <i>PARK7</i> genes lead to sex-specific serum metabolic changes in patients with Parkinson’s disease

2026-01-15

Abstract excerpt

Sex differences significantly influence the pathophysiology of Parkinson’s disease (PD). However, it remains unclear whether sex differences affect blood metabolome profiles in patients with PD-related gene mutations compared to healthy controls (HCs). Here, we conducted a 1 H-Nuclear Magnetic Resonance (NMR) metabolomic analysis of serum samples from a defined cohort of patients carrying variants in LRRK2 (n=17...

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Literature Corpus work
011901aa-b06c-55d1-86d5-40be22241e65
DOI
10.64898/2026.01.13.26344011
Open publication

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Mutations in the <i>GBA1</i> , <i>LRRK2</i> , <i>TMEM175</i> , <i>PARK2</i> , <i>PINK1</i> , and <i>PARK7</i> genes lead to sex-specific serum metabolic changes in patients with Parkinson’s diseaseDOI 10.64898/2026.01.13.26344011
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